description
APC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein Cdc20. APC/C:Cdc20 promotes the multiubiquitination and ordered degradation of Cyclin A and Nek2 degradation in prometaphase followed by Cyclin B and securin in metaphase (Reviewed in Castro et al., 2005)

external resources
NCBI:1269842
REACTOME:R-HSA-176814
PUBMED:15678131

genes
BUB1B , CCNA2 , CCNB1 , CDK1 , CDC20 , CDC27 , MAD2L1 , NEK2 , PLK1 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , UBA52 , UBB , UBC , UBE2D1 , UBE2E1 , SEM1 , CDC23 , CDC16 , CCNA1 , BUB3 , PTTG1 , PSMF1 , PSMD6 , PSME3 , PSMD14 , ANAPC10 , UBE2C , PSME4 , ANAPC15 , ANAPC2 , ANAPC4 , ANAPC5 , ANAPC7 , ANAPC11 , ANAPC1 , ANAPC16 , PSMB11 , PSMA8 , CDC26 , C7orf76 , LOC100506136 ,