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- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
description
APC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein Cdc20. APC/C:Cdc20 promotes the multiubiquitination and ordered degradation of Cyclin A and Nek2 degradation in prometaphase followed by Cyclin B and securin in metaphase (Reviewed in Castro et al., 2005)
external resources
NCBI:1269842
REACTOME:R-HSA-176814
PUBMED:15678131
genes
BUB1B
,
CCNA2
,
CCNB1
,
CDK1
,
CDC20
,
CDC27
,
MAD2L1
,
NEK2
,
PLK1
,
PSMA1
,
PSMA2
,
PSMA3
,
PSMA4
,
PSMA5
,
PSMA6
,
PSMA7
,
PSMB1
,
PSMB2
,
PSMB3
,
PSMB4
,
PSMB5
,
PSMB6
,
PSMB7
,
PSMB8
,
PSMB9
,
PSMB10
,
PSMC1
,
PSMC2
,
PSMC3
,
PSMC4
,
PSMC5
,
PSMC6
,
PSMD1
,
PSMD2
,
PSMD3
,
PSMD4
,
PSMD5
,
PSMD7
,
PSMD8
,
PSMD9
,
PSMD10
,
PSMD11
,
PSMD12
,
PSMD13
,
PSME1
,
PSME2
,
RPS27A
,
UBA52
,
UBB
,
UBC
,
UBE2D1
,
UBE2E1
,
SEM1
,
CDC23
,
CDC16
,
CCNA1
,
BUB3
,
PTTG1
,
PSMF1
,
PSMD6
,
PSME3
,
PSMD14
,
ANAPC10
,
UBE2C
,
PSME4
,
ANAPC15
,
ANAPC2
,
ANAPC4
,
ANAPC5
,
ANAPC7
,
ANAPC11
,
ANAPC1
,
ANAPC16
,
PSMB11
,
PSMA8
,
CDC26
,
C7orf76
,
LOC100506136
,