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description
Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005

external resources
NCBI:1269844
REACTOME:R-HSA-176409
PUBMED:15949434
PUBMED:10465783

genes
BUB1B , CCNA2 , CCNB1 , CDK1 , CDC20 , CDC27 , MAD2L1 , NEK2 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , UBA52 , UBB , UBC , UBE2D1 , UBE2E1 , SEM1 , CDC23 , CDC16 , CCNA1 , BUB3 , PTTG1 , PSMF1 , PSMD6 , PSME3 , PSMD14 , ANAPC10 , UBE2C , PSME4 , ANAPC15 , ANAPC2 , ANAPC4 , ANAPC5 , ANAPC7 , ANAPC11 , ANAPC1 , ANAPC16 , PSMB11 , PSMA8 , CDC26 , C7orf76 , LOC100506136 ,