description
The activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. Phosphorylation of both the APC/C complex and Cdh1 regulate this conversion. During mitosis, several APC/C subunits are phosphorylated increasing the activity of APC/C:Cdc20. However, phosphorylation of Cdh1 by mitotic Cyclin:Cdk complexes prevents it from activating the APC/C. Dephosphorylation of Cdh1 in late anaphase by Cdc14a results in the activation of APC/C:Cdh1 (reviewed in Castro et al, 2005)

external resources
NCBI:1269850
REACTOME:R-HSA-176407
PUBMED:15678131

genes
CDC20 , CDC27 , UBE2D1 , UBE2E1 , CDC14A , CDC23 , CDC16 , ANAPC10 , UBE2C , ANAPC15 , ANAPC2 , ANAPC4 , FZR1 , ANAPC5 , ANAPC7 , ANAPC11 , ANAPC1 , ANAPC16 , CDC26 ,