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- Deposition of new CENPA-containing nucleosomes at the centromere
description
Eukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophase/early G1 phase of the cell cycle. Once deposited, nucleosomes containing CENPA remain stably associated with the centromere and are partitioned equally to daughter centromeres during S phase. A current model proposes that pre-existing CENPA at the centromere drives recruitment of new CENPA, however this has not been proved.The deposition process requires at least 3 complexes: the Mis18 complex, HJURP complex, and the RSF complex. HJURP binds newly synthesized CENPA-H4 tetramers before deposition and brings them to the centromere for deposition in new CENPA-containing nucleosomes. The exact mechanism of deposition remains unknown
external resources
NCBI:1269855
REACTOME:R-HSA-606279
PUBMED:20080577
PUBMED:19410545
PUBMED:19629040
PUBMED:19410544
PUBMED:19660450
PUBMED:19590885
PUBMED:19410539
PUBMED:17339380
genes
CENPA
,
CENPC
,
CENPI
,
HIST1H2AE
,
HIST1H2AD
,
H2AFX
,
H2AFZ
,
HIST1H2BD
,
HIST1H2BB
,
NPM1
,
RBBP4
,
RBBP7
,
HIST1H4I
,
HIST1H2AJ
,
HIST1H2AC
,
HIST1H2AB
,
HIST2H2AA3
,
HIST2H2AC
,
HIST1H2BG
,
HIST1H2BL
,
HIST1H2BN
,
HIST1H2BM
,
HIST1H2BF
,
HIST1H2BE
,
HIST1H2BH
,
HIST1H2BI
,
HIST1H2BC
,
HIST1H2BO
,
HIST2H2BE
,
HIST1H4A
,
HIST1H4D
,
HIST1H4F
,
HIST1H4K
,
HIST1H4J
,
HIST1H4C
,
HIST1H4H
,
HIST1H4B
,
HIST1H4E
,
HIST1H4L
,
HIST2H4A
,
SMARCA5
,
RUVBL1
,
HIST1H2BJ
,
OIP5
,
ITGB3BP
,
RSF1
,
MIS18A
,
CENPQ
,
MIS18BP1
,
HJURP
,
H2AFJ
,
CENPN
,
KNL1
,
CENPK
,
CENPH
,
CENPM
,
CENPO
,
CENPU
,
CENPT
,
HIST1H2BK
,
CENPL
,
H2AFV
,
HIST4H4
,
HIST3H2BB
,
CENPX
,
HIST1H2BA
,
CENPS
,
CENPW
,
CENPP
,
H2AFB1
,
HIST2H4B
,
HIST2H2AA4
,