description
Eukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophase/early G1 phase of the cell cycle. Once deposited, nucleosomes containing CENPA remain stably associated with the centromere and are partitioned equally to daughter centromeres during S phase. A current model proposes that pre-existing CENPA at the centromere drives recruitment of new CENPA, however this has not been proved.The deposition process requires at least 3 complexes: the Mis18 complex, HJURP complex, and the RSF complex. HJURP binds newly synthesized CENPA-H4 tetramers before deposition and brings them to the centromere for deposition in new CENPA-containing nucleosomes. The exact mechanism of deposition remains unknown

external resources
NCBI:1269855
REACTOME:R-HSA-606279
PUBMED:20080577
PUBMED:19410545
PUBMED:19629040
PUBMED:19410544
PUBMED:19660450
PUBMED:19590885
PUBMED:19410539
PUBMED:17339380

genes
CENPA , CENPC , CENPI , HIST1H2AE , HIST1H2AD , H2AFX , H2AFZ , HIST1H2BD , HIST1H2BB , NPM1 , RBBP4 , RBBP7 , HIST1H4I , HIST1H2AJ , HIST1H2AC , HIST1H2AB , HIST2H2AA3 , HIST2H2AC , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , HIST1H4A , HIST1H4D , HIST1H4F , HIST1H4K , HIST1H4J , HIST1H4C , HIST1H4H , HIST1H4B , HIST1H4E , HIST1H4L , HIST2H4A , SMARCA5 , RUVBL1 , HIST1H2BJ , OIP5 , ITGB3BP , RSF1 , MIS18A , CENPQ , MIS18BP1 , HJURP , H2AFJ , CENPN , KNL1 , CENPK , CENPH , CENPM , CENPO , CENPU , CENPT , HIST1H2BK , CENPL , H2AFV , HIST4H4 , HIST3H2BB , CENPX , HIST1H2BA , CENPS , CENPW , CENPP , H2AFB1 , HIST2H4B , HIST2H2AA4 ,