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description
After the primers are synthesized on the G-Rich strand, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. The non-processive nature of pol alpha catalytic activity and the tight binding of Replication Factor C to the primer-template junction presumably lead to the turnover of the pol alpha:primase complex. After the Pol alpha-primase primase complex is displaced from the primer, the proliferating cell nuclear antigen (PCNA) binds to form a "sliding clamp" structure. Replication Factor C then dissociates, and DNA polymerase delta binds and catalyzes the processive synthesis of DNA

external resources
NCBI:1269861
REACTOME:R-HSA-174411
PUBMED:1967833
PUBMED:1671046
PUBMED:1670772

genes
PCNA , POLA1 , POLD1 , POLD2 , PRIM1 , RFC1 , RFC2 , RFC3 , RFC4 , RFC5 , POLD3 , POLA2 , POLD4 ,