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- Polymerase switching on the C-strand of the telomere
description
After the primers are synthesized on the G-Rich strand, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. The non-processive nature of pol alpha catalytic activity and the tight binding of Replication Factor C to the primer-template junction presumably lead to the turnover of the pol alpha:primase complex. After the Pol alpha-primase primase complex is displaced from the primer, the proliferating cell nuclear antigen (PCNA) binds to form a "sliding clamp" structure. Replication Factor C then dissociates, and DNA polymerase delta binds and catalyzes the processive synthesis of DNA
external resources
NCBI:1269861
REACTOME:R-HSA-174411
PUBMED:1967833
PUBMED:1671046
PUBMED:1670772
genes
PCNA
,
POLA1
,
POLD1
,
POLD2
,
PRIM1
,
RFC1
,
RFC2
,
RFC3
,
RFC4
,
RFC5
,
POLD3
,
POLA2
,
POLD4
,