description
There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat

external resources
NCBI:1269881
REACTOME:R-HSA-421837

genes
AP1B1 , AP1G1 , APP , ARF1 , ARRB1 , AP1S1 , AP3S1 , CLTA , CLTB , CLTC , CPD , CTSZ , DNASE2 , DNM2 , FTH1 , FTL , GAK , BLOC1S1 , GNS , GOLGB1 , HSPA8 , IGF2R , M6PR , OCRL , PIK3C2A , RAB5C , SORT1 , SH3GL2 , SNX2 , STX4 , VAMP2 , VAMP7 , TFRC , TPD52 , TPD52L1 , PICALM , AP3B1 , VAMP8 , GBF1 , SNAP23 , NAPA , AP1S2 , AP1G2 , AP1M1 , HIP1R , HGS , AP4M1 , CLINT1 , PUM1 , DNAJC6 , AP1M2 , TGOLN2 , AP4B1 , AP4S1 , AP4E1 , SNAPIN , NECAP1 , BLOC1S6 , SNX5 , CHMP2A , SNX9 , TBC1D8B , BLOC1S4 , ACBD3 , TXNDC5 , DTNBP1 , AP1S3 , CLVS2 , SH3D19 , CLVS1 , YIPF6 , BLOC1S3 , MIR3620 ,