description
Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+ - and/or Cl- -dependent transport of basic anions [e.g. HCO3-, (CO3)2-] in various tissues and cell types (in addition to pH regulation, specific members of this family also contribute to vectorial trans-epithelial base transport in several organ systems including the kidney, pancreas, and eye) (Pushkin A and Kurtz I, 2006); SLC8 is a group of Na+/Ca2+ exchangers (SLC8A1 is involved in cardiac contractility) (Quednau BD et al, 2004); SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers (Altimimi HF and Schnetkamp PP, 2007); SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons (Orlowski J and Grinstein S, 2004); SLC12 functions as Na+, K+ and Cl- ion electroneutral symporters (Hebert SC et al, 2004); SLC26 is the trans-epithelial multifunctional anion (e.g. sulfate, oxalate, HCO-, Cl-) exchanger family, important in cartilage development, production of thyroid hormone, sound amplification in the cochlea etc (Sindic A et al, 2007; Dorwart MR et al, 2008; Ashmore J, 2008). SLC34 is an important Type II Na+/(HPO4)2- symporter (Forster IC et al, 2006; Virkki LV et al, 2007); SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/(H2PO4)- symporter (Collins JF et al, 2004; Virkki LV et al, 2007). Eight SLC gene families are involved in the transport of amino acids and oligopeptides

external resources
NCBI:1269908
REACTOME:R-HSA-425393
PUBMED:19164095
PUBMED:16461757
PUBMED:18195086
PUBMED:18400693
PUBMED:17581921
PUBMED:12845533
PUBMED:18690016
PUBMED:16955105
PUBMED:17693766
PUBMED:12759754
PUBMED:12739168
PUBMED:12734757

genes
CALM1 , CALM2 , CALM3 , SLC25A10 , CTNS , SLC26A3 , SLC26A2 , SLC26A4 , SLC1A1 , SLC1A2 , SLC1A3 , SLC4A3 , SLC1A4 , SLC1A5 , SLC1A6 , SLC1A7 , SLC3A1 , SLC3A2 , SLC4A1 , SLC4A2 , SLC5A5 , SLC6A6 , SLC6A12 , SLC7A1 , SLC7A2 , SLC8A2 , SLC8A1 , SLC8A3 , SLC9A1 , SLC9A2 , SLC9A3 , SLC9A5 , SLC12A1 , SLC12A2 , SLC12A3 , SLC12A4 , SLC15A1 , SLC15A2 , SLC17A1 , SLC34A1 , SLC20A1 , SLC20A2 , SRI , SLC7A5 , SLC43A1 , SLC4A4 , SLC7A7 , SLC7A6 , SLC24A1 , SLC4A7 , SLC4A8 , SLC12A6 , SLC9A6 , SLC34A2 , SLC12A7 , SLC26A1 , SLC38A3 , SLC7A9 , SLC6A14 , SLC9A8 , AHCYL2 , SLC7A8 , SLC7A11 , SLC24A2 , SLC17A5 , SLC15A3 , SLC38A2 , SLC6A20 , SLC38A4 , SLC6A15 , SLC7A10 , SLC17A7 , SLC17A6 , SLC4A10 , SLC24A3 , SLC12A5 , SLC4A5 , SLC26A6 , SLC25A22 , SLC8B1 , SLC38A1 , SLC4A9 , SLC25A18 , SLC9A7 , SLC7A3 , SLC38A5 , SLC26A9 , SLC26A7 , SLC25A26 , SLC16A10 , SLC15A4 , SLC24A4 , SLC43A2 , SLC32A1 , SLC34A3 , SLC36A2 , SLC5A12 , SLC5A8 , SLC36A1 , SLC17A8 , SLC24A5 , SLC26A11 , SLC9A9 , SLC6A19 , SLC6A18 , SLC9A4 ,