description
Zinc is an essential element for all organisms because it serves as a catalytic or structural cofactor for many different proteins. Cellular zinc homoeostasis is co-ordinated through Zn2+-specific transporters which are members of two distinct gene families. Members of the SLC39 gene family (ZRTL-like import proteins1-14, ZIP1-14) are responsible for Zn2+ import into the cytoplasm, either across the plasma membrane or out of intracellular organelles. In contrast, members of the SLC30 gene family (zinc transporters 1-10, ZnT1-10) export Zn2+ from the cytoplasm, either across the plasma membrane into the extracellular space or into intracellular organelles (Murakami M and Hirano T, 2008; Devirgiliis C et al, 2007; Eide DJ, 2006)

external resources
NCBI:1269931
REACTOME:R-HSA-435354
PUBMED:18754861
PUBMED:16675045
PUBMED:17374385

genes
SLC30A1 , SLC30A2 , SLC30A3 , SLC39A7 , SLC39A14 , SLC39A6 , SLC39A1 , SLC39A3 , SLC39A2 , SLC39A4 , SLC30A6 , SLC39A10 , SLC39A8 , SLC30A5 , SLC30A7 , SLC30A8 , SLC39A5 ,