description
The SLC22 gene family of solute carriers function as organic cation transporters (OCTs), cation/zwitterion transporters (OCTNs) and organic anion transporters (OATs). The SLC22 family belongs to the major facilitator superfamily and comprises uniporters, symporters and antiporters.Most of this family are polyspecific transporters. Since many of these transporters are expressed in the liver, kidney and intestine, they play an important role in drug absorption and excretion. Substrates include xenobiotics, drugs, and endogenous amine compounds (Koepsell H and Endou H, 2004)

external resources
NCBI:1269936
REACTOME:R-HSA-549132
PUBMED:12883891

genes
RUNX1 , SLC22A18 , RSC1A1 , SLC22A1 , SLC22A3 , SLC22A2 , SLC22A4 , SLC22A5 , SLC22A6 , SLC22A8 , SLC22A7 , SLC22A15 , SLC22A11 , SLC22A16 , SLC22A12 , LOC100506403 ,