description
Ion channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore for the flow of ions. There are different types of ion channels. P-type ATPases undergo conformational changes to translocate ions. Ligand-gated ion channels operate like a gate, opened or closed by a chemical signal. Voltage-gated ion channels are activated by changes in electrical potential difference at the membrane (Purves, 2001; Kuhlbrandt, 2004)

external resources
NCBI:1269950
REACTOME:R-HSA-983712
PUBMED:15071553

genes
ASIC2 , ASIC1 , ASPH , ATP1A1 , ATP1A2 , ATP1A3 , ATP12A , ATP1A4 , ATP1B1 , ATP1B2 , ATP1B3 , FXYD2 , ATP2A1 , ATP2A2 , ATP2A3 , ATP2B1 , ATP2B2 , ATP2B3 , ATP2B4 , ATP4A , ATP4B , ATP6V1A , ATP6V1B1 , ATP6V1B2 , ATP6V0C , ATP6V1C1 , ATP6V1E1 , ATP6V0B , ATP6V1G2 , ATP6V0A1 , ATP6AP1 , ATP7A , ATP7B , CALM1 , CALM2 , CALM3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CLCA1 , CLCN1 , CLCN2 , CLCN3 , CLCN4 , CLCN5 , CLCN6 , CLCN7 , CLCNKA , CLCNKB , CLIC2 , TSC22D3 , STOM , FKBP1B , GABRA1 , GABRA2 , GABRA3 , GABRA4 , GABRA5 , GABRA6 , GABRB1 , GABRB2 , GABRB3 , GABRG2 , GABRG3 , GABRR1 , GABRR2 , GLRA1 , GLRA2 , GLRB , HTR3A , TRPM1 , ATP8B1 , FXYD1 , FXYD3 , PLN , RAF1 , RPS27A , RYR1 , RYR2 , RYR3 , SCNN1A , SCNN1B , SCNN1D , SCNN1G , SGK1 , SLN , SRI , TRPC1 , TRPC3 , TRPC4 , TRPC5 , TRPC6 , TRPM2 , UBA52 , UBB , UBC , BEST1 , TRPV1 , BSND , GLRA3 , TRPA1 , ATP6V0E1 , ATP6V0D1 , HTR3B , ATP6V1F , ASIC3 , ATP6V1G1 , CLCA3P , CLCA2 , ATP2C2 , ATP9A , SGK2 , TCIRG1 , TRDN , ATP8A1 , SLC17A3 , WWP1 , CLCA4 , ATP10B , ATP11B , ARHGEF9 , ATP11A , NEDD4L , ATP13A2 , ATP6V0A2 , SGK3 , TRPC4AP , ATP2C1 , OSTM1 , TRPM5 , ATP6V0A4 , ANO7 , CUTC , PDZD11 , ATP6V1D , TRPV2 , ATP6V1H , ATP8A2 , ASIC5 , TPCN1 , FXYD7 , FXYD6 , FXYD4 , TRPM4 , TRPM7 , BEST2 , ANO1 , ANO10 , MCOLN3 , TRPV6 , ASIC4 , GABRQ , TRPV5 , ANO2 , TRPC7 , ATP13A1 , MCOLN1 , ATP10A , ATP8B2 , ATP10D , TTYH1 , UNC79 , ANO8 , TRPV4 , ANO3 , WNK1 , WNK4 , WNK3 , WNK2 , TRPM8 , ATP8B4 , TRPM3 , TTYH3 , ATP13A4 , ATP6V1E2 , TTYH2 , ANO4 , ATP6V1G3 , SLC9B2 , TRPM6 , BEST3 , ATP8B3 , SLC9B1 , ATP6V0E2 , STOML3 , TRPV3 , HTR3C , ANO6 , HTR3D , GABRR3 , ANO5 , TPCN2 , ATP6V0D2 , ATP6V1C2 , MCOLN2 , NALCN , BEST4 , SLC9C2 , UNC80 , HTR3E , SLC9C1 , ATP11C , ANO9 , ATP13A5 , ATP9B , GLRA4 , MIR5010 ,