description
Ion channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et al. 2012, Deval et al. 2010) and the transient receptor potential channels (TRPCs) (Takahashi et al. 2012, Numata et al. 2011 in "TRP Channels" Zhu, MX editor, CRC Press, 2011, Ramsey et al. 2006, Montell 2005). Many channels are sensitive to changes in calcium (Ca2+) levels, both inside and outside the cell. Examples are protein tweety homologs 2 and 3 (TTYH2, 3) (Suzuki 2006), bestrophins 1-4 (BEST1-4) (Sun et al. 2002, Tsunenari et al. 2003, Kunzelmann et al. 2009, Hartzell et al. 2008) and ryanodine receptor tetramers (RYRs) (Beard et al. 2009)

external resources
NCBI:1269953
REACTOME:R-HSA-2672351
PUBMED:15728426
PUBMED:16460286
PUBMED:12907679
PUBMED:18391176
PUBMED:19278523
PUBMED:11904445
PUBMED:22934072
PUBMED:20807551
PUBMED:19783045
PUBMED:16219661
PUBMED:21932071
PUBMED:22277752

genes
ASIC2 , ASIC1 , ASPH , CALM1 , CALM2 , CALM3 , CLCA1 , CLCN1 , CLCN2 , CLCN3 , CLCN4 , CLCN5 , CLCN6 , CLCN7 , CLCNKA , CLCNKB , CLIC2 , TSC22D3 , STOM , FKBP1B , TRPM1 , RAF1 , RPS27A , RYR1 , RYR2 , RYR3 , SCNN1A , SCNN1B , SCNN1D , SCNN1G , SGK1 , SRI , TRPC1 , TRPC3 , TRPC4 , TRPC5 , TRPC6 , TRPM2 , UBA52 , UBB , UBC , BEST1 , TRPV1 , BSND , TRPA1 , ASIC3 , CLCA3P , CLCA2 , SGK2 , TRDN , SLC17A3 , WWP1 , CLCA4 , NEDD4L , SGK3 , TRPC4AP , OSTM1 , TRPM5 , ANO7 , TRPV2 , ASIC5 , TPCN1 , TRPM4 , TRPM7 , BEST2 , ANO1 , ANO10 , MCOLN3 , TRPV6 , ASIC4 , TRPV5 , ANO2 , TRPC7 , MCOLN1 , TTYH1 , UNC79 , ANO8 , TRPV4 , ANO3 , WNK1 , WNK4 , WNK3 , WNK2 , TRPM8 , TRPM3 , TTYH3 , TTYH2 , ANO4 , SLC9B2 , TRPM6 , BEST3 , SLC9B1 , STOML3 , TRPV3 , ANO6 , ANO5 , TPCN2 , MCOLN2 , NALCN , BEST4 , SLC9C2 , UNC80 , SLC9C1 , ANO9 ,