description
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels. PPAR-alpha is a type II nuclear receptor (its subcellular location does not depend on ligand binding). PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha), another type II nuclear receptor. PPAR-alpha is activated by binding fatty acid ligands, especially polyunsaturated fatty acids having 18-22 carbon groups and 2-6 double bonds. The PPAR-alpha:RXR-alpha heterodimer binds peroxisome proliferator receptor elements (PPREs) in and around target genes. Binding of fatty acids and synthetic ligands causes a conformational change in PPAR-alpha such that it releases the corepressors and binds coactivators (CBP-SRC-HAT complex, ASC complex, and TRAP-Mediator complex) which initiate transcription of the target genes.Target genes of PPAR-alpha participate in fatty acid transport, fatty acid oxidation, triglyceride clearance, lipoprotein production, and cholesterol homeostasis

external resources
NCBI:1270029
REACTOME:R-HSA-400206
PUBMED:18288277
PUBMED:10529898
PUBMED:16476485
PUBMED:16503871

genes
ABCA1 , ACADM , ACOX1 , PLIN2 , AGT , AHR , ALAS1 , APOA1 , APOA2 , ARNT , ARNTL , CCNC , CD36 , CDK8 , CPT1A , CPT2 , CREBBP , CTGF , CYP1A1 , CYP4A11 , CYP7A1 , EP300 , ESRRA , FABP1 , ACSL1 , FDFT1 , FHL2 , HMGCR , HMGCS1 , HMGCS2 , FADS1 , ME1 , MTF1 , NFYA , NFYB , NFYC , NPAS2 , NRF1 , ABCB4 , PPARA , PPARG , MED1 , RORA , RXRA , SMARCD3 , SP1 , SREBF1 , SREBF2 , SULT2A1 , MED22 , TBL1X , TEAD1 , TEAD4 , TEAD3 , TXNRD1 , NCOA3 , TEAD2 , NCOA1 , PEX11A , HDAC3 , MED14 , MED21 , MED23 , MED17 , MED26 , MED27 , MED7 , MED20 , NR1D1 , CLOCK , NCOR1 , NCOR2 , MED24 , ARNT2 , THRAP3 , MED12 , MED13 , NR1H4 , MED6 , MED16 , YAP1 , CARM1 , NCOA2 , PPARGC1A , GLIPR1 , NCOA6 , CDK19 , RGL1 , SIN3B , MED13L , WWTR1 , SIN3A , TIAM2 , ANKRD1 , TNFRSF21 , MED4 , GRHL1 , G0S2 , MED31 , ANGPTL4 , MED15 , UGT1A9 , MED18 , MED9 , MED29 , AHRR , TRIB3 , TBL1XR1 , CHD9 , MED28 , MED25 , MED10 , FAM120B , HELZ2 , MED30 , TGS1 , MED8 , APOA5 , PPARGC1B , MED19 , SLC27A1 , MED11 , MIR1281 , MIR1908 ,