description
The set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor elements (PPREs) in their promoters and include: 1) genes involved in fatty acid oxidation and ketogenesis (Acox1, Cyp4a, Acadm, Hmgcs2);2) genes involved in fatty acid transport (Cd36, , Slc27a1, Fabp1, Cpt1a, Cpt2);3) genes involved in producing fatty acids and very low density lipoproteins (Me1, Scd1);4) genes encoding apolipoproteins (Apoa1, Apoa2, Apoa5);5) genes involved in triglyceride clearance ( Angptl4);6) genes involved in glycerol metabolism (Gpd1 in mouse);7) genes involved in glucose metabolism (Pdk4);8) genes involved in peroxisome proliferation (Pex11a);9) genes involved in lipid storage (Plin, Adfp).Many other genes are known to be regulated by PPAR-alpha but whether their regulation is direct or indirect remains to be found. These genes include: ACACA, FAS, SREBP1, FADS1, DGAT1, ABCA1, PLTP, ABCB4, UGT2B4, SULT2A1, Pnpla2, Acsl1, Slc27a4, many Acot genes, and others (reviewed in Rakhshandehroo et al. 2010)

external resources
NCBI:1270030
REACTOME:R-HSA-1989781
PUBMED:10529898
PUBMED:18288277
PUBMED:11330046
PUBMED:20936127
PUBMED:14999402

genes
ABCA1 , ACADM , ACOX1 , PLIN2 , AGT , AHR , ALAS1 , APOA1 , APOA2 , ARNT , ARNTL , CCNC , CD36 , CDK8 , CPT1A , CPT2 , CREBBP , CTGF , CYP1A1 , CYP4A11 , CYP7A1 , EP300 , ESRRA , FABP1 , ACSL1 , FDFT1 , FHL2 , HMGCR , HMGCS1 , HMGCS2 , FADS1 , ME1 , MTF1 , NFYA , NFYB , NFYC , NPAS2 , NRF1 , ABCB4 , PPARA , PPARG , MED1 , RORA , RXRA , SMARCD3 , SP1 , SREBF1 , SREBF2 , SULT2A1 , MED22 , TBL1X , TEAD1 , TEAD4 , TEAD3 , TXNRD1 , NCOA3 , TEAD2 , NCOA1 , PEX11A , HDAC3 , MED14 , MED21 , MED23 , MED17 , MED26 , MED27 , MED7 , MED20 , NR1D1 , CLOCK , NCOR1 , MED24 , ARNT2 , THRAP3 , MED12 , MED13 , NR1H4 , MED6 , MED16 , YAP1 , CARM1 , NCOA2 , PPARGC1A , GLIPR1 , NCOA6 , CDK19 , RGL1 , MED13L , WWTR1 , TIAM2 , ANKRD1 , TNFRSF21 , MED4 , GRHL1 , G0S2 , MED31 , ANGPTL4 , MED15 , UGT1A9 , MED18 , MED9 , MED29 , AHRR , TRIB3 , TBL1XR1 , CHD9 , MED28 , MED25 , MED10 , FAM120B , HELZ2 , MED30 , TGS1 , MED8 , APOA5 , PPARGC1B , MED19 , SLC27A1 , MED11 , MIR1281 , MIR1908 ,