description
In the de novo synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of sn-1 by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT). In addition to this, PA is also formed when phosphatidylcholine (PC) is hydrolyzed by phospholipases D1 and D2 (PLD1 and 2). PA is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by acyltransferases (Ghomashchi et al. 2010, Singer et al. 2002, Prasad et al. 2011, Shindou & Shimizu 2009, Cao et al. 2006)

external resources
NCBI:1270055
REACTOME:R-HSA-1483166
PUBMED:21173190
PUBMED:20705608
PUBMED:18718904
PUBMED:17170135
PUBMED:12359733

genes
ALPI , GPD1 , PLA2G1B , PLA2G2A , PLA2G4A , PLA2G5 , PLD1 , PLD2 , PLA2G10 , GNPAT , AGPAT1 , AGPAT2 , PLA2R1 , GPD1L , DDHD2 , PLA2G2D , PLA2G2E , ACP6 , AGPAT5 , AGPAT3 , AGPAT4 , GPAM , PLA2G2F , LPCAT1 , DDHD1 , PLA2G12A , GPAT3 , GPAT4 , GPAT2 , LCLAT1 , LPCAT4 , PLA2G4D , PLA2G4B ,