description
At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Zhang et al. 1997, Gurung et al. 2003, Guo et al. 1999, Vanhaesebroeck et al. 1997, Tolias et al. 1998, Schaletzky et al. 2003, Kim et al. 2002, Clarke et al. 2010). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity (Berger et al. 2006, Zou et al. 2012)

external resources
NCBI:1270077
REACTOME:R-HSA-1660499
PUBMED:16399794
PUBMED:12646134
PUBMED:10224048
PUBMED:9113989
PUBMED:9211928
PUBMED:12536145
PUBMED:22647598
PUBMED:11733541
PUBMED:9660759
PUBMED:19896968

genes
ARF1 , BMX , INPP4A , INPP5D , INPPL1 , MTM1 , OCRL , PIK3C2A , PIK3C2B , PIK3C2G , PIK3CA , PIK3CB , PIK3CD , PIK3CG , PIK3R1 , PIK3R2 , PIP4K2A , PTEN , PTPN13 , RAB4A , RAB5A , PIP5K1A , PIP5K1B , PIP4K2B , PIK3R3 , MTMR1 , INPP4B , SYNJ1 , SYNJ2 , MTMR3 , MTMR6 , PLEKHA6 , PIP5K1C , PIK3R5 , INPP5J , RAB14 , INPP5K , PLEKHA5 , PI4K2B , PI4K2A , PLEKHA4 , PLEKHA1 , PLEKHA2 , MTMR14 , PLEKHA3 , PIP4K2C , RUFY1 , PLEKHA8 , PIK3R6 , MIR3620 ,