description
AMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates a wide array of target proteins, as shown in the figure below (reproduced from (Hardie et al. 2003), with the permission of D.G. Hardie). These targets include ChREBP (Carbohydrate Response Element Binding Protein), whose inactivation by phosphorylation reduces transcription of key enzymes of the glycolytic and lipogenic pathways

external resources
NCBI:1270112
REACTOME:R-HSA-163680
PUBMED:15509864
PUBMED:12829246
PUBMED:11724780
PUBMED:10698692

genes
PRKAA2 , PRKAB2 , STK11 , ADIPOQ , MLXIPL , ADIPOR1 , PRKAG2 , ADIPOR2 ,