description
The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to drive ATP synthesis

external resources
NCBI:1270121
REACTOME:R-HSA-1428517

genes
ACO2 , ATP5F1A , ATP5F1B , ATP5F1C , ATP5F1D , ATP5F1E , ATP5PB , ATP5MC1 , ATP5MC2 , ATP5MC3 , ATP5ME , ATP5PF , ATP5PO , BSG , COX4I1 , COX5B , COX6A1 , COX6B1 , COX6C , COX7B , COX7C , COX8A , COX11 , CS , CYC1 , DLAT , DLD , DLST , ETFA , ETFB , ETFDH , FH , GLO1 , HAGH , IDH2 , IDH3A , IDH3B , IDH3G , LDHA , LDHB , LDHC , MDH2 , MT-ATP6 , MT-ATP8 , MT-CO1 , MT-CO2 , MT-CO3 , MT-CYB , MT-ND1 , MT-ND2 , MT-ND3 , MT-ND4 , MT-ND5 , MT-ND6 , NDUFA1 , NDUFA2 , NDUFA3 , NDUFA4 , NDUFA5 , NDUFA6 , NDUFA7 , NDUFA8 , NDUFA9 , NDUFA10 , NDUFAB1 , NDUFB1 , NDUFB2 , NDUFB3 , NDUFB4 , NDUFB5 , NDUFB6 , NDUFB7 , NDUFB8 , NDUFB9 , NDUFB10 , NDUFC1 , NDUFC2 , NDUFS1 , NDUFS2 , NDUFS3 , NDUFV1 , NDUFS4 , NDUFS5 , NDUFS6 , NDUFS8 , NDUFV2 , NDUFV3 , OGDH , PDHA1 , PDHB , PDK1 , PDK2 , PDK3 , PDK4 , PPARD , RXRA , SCO1 , SDHA , SDHB , SDHC , SDHD , SLC16A1 , SURF1 , UCP1 , UCP2 , UCP3 , UQCRB , UQCRC1 , UQCRC2 , UQCRFS1 , UQCRH , PDHX , SUCLG2 , SUCLG1 , SUCLA2 , SLC25A14 , SLC16A3 , COX7A2L , COX5A , SLC25A27 , ATP5MF , SCO2 , LRPPRC , TRAP1 , ATP5PD , ATP5MG , UQCR11 , NNT , SLC16A8 , MPC2 , NDUFAF3 , UQCRQ , ATP5S , ACAD9 , NDUFAF4 , UQCR10 , NDUFA13 , NDUFAF1 , TACO1 , COX16 , ECSIT , TIMMDC1 , MPC1 , CYCS , NDUFB11 , PDP1 , PDPR , NDUFAF7 , TMEM126B , NDUFA12 , PDP2 , NDUFAF5 , L2HGDH , COQ10B , NUBPL , COX14 , NDUFAF2 , LDHAL6B , COQ10A , COX20 , NDUFA11 , NDUFAF6 , ADHFE1 , LDHAL6A , COX18 , NDUFS7 , D2HGDH , MIR3607 , MIR4691 ,