description
Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling proteins to generate heat, a reaction in brown fat that may be important in regulation of body temperature in newborn children

external resources
NCBI:1270127
REACTOME:R-HSA-163200

genes
ATP5F1A , ATP5F1B , ATP5F1C , ATP5F1D , ATP5F1E , ATP5PB , ATP5MC1 , ATP5MC2 , ATP5MC3 , ATP5ME , ATP5PF , ATP5PO , COX4I1 , COX5B , COX6A1 , COX6B1 , COX6C , COX7B , COX7C , COX8A , COX11 , CYC1 , ETFA , ETFB , ETFDH , MT-ATP6 , MT-ATP8 , MT-CO1 , MT-CO2 , MT-CO3 , MT-CYB , MT-ND1 , MT-ND2 , MT-ND3 , MT-ND4 , MT-ND5 , MT-ND6 , NDUFA1 , NDUFA2 , NDUFA3 , NDUFA4 , NDUFA5 , NDUFA6 , NDUFA7 , NDUFA8 , NDUFA9 , NDUFA10 , NDUFAB1 , NDUFB1 , NDUFB2 , NDUFB3 , NDUFB4 , NDUFB5 , NDUFB6 , NDUFB7 , NDUFB8 , NDUFB9 , NDUFB10 , NDUFC1 , NDUFC2 , NDUFS1 , NDUFS2 , NDUFS3 , NDUFV1 , NDUFS4 , NDUFS5 , NDUFS6 , NDUFS8 , NDUFV2 , NDUFV3 , SCO1 , SDHA , SDHB , SDHC , SDHD , SURF1 , UCP1 , UCP2 , UCP3 , UQCRB , UQCRC1 , UQCRC2 , UQCRFS1 , UQCRH , SLC25A14 , COX7A2L , COX5A , SLC25A27 , ATP5MF , SCO2 , LRPPRC , TRAP1 , ATP5PD , ATP5MG , UQCR11 , NDUFAF3 , UQCRQ , ATP5S , ACAD9 , NDUFAF4 , UQCR10 , NDUFA13 , NDUFAF1 , TACO1 , COX16 , ECSIT , TIMMDC1 , CYCS , NDUFB11 , NDUFAF7 , TMEM126B , NDUFA12 , NDUFAF5 , COQ10B , NUBPL , COX14 , NDUFAF2 , COQ10A , COX20 , NDUFA11 , NDUFAF6 , COX18 , NDUFS7 , MIR3607 , MIR4691 ,