description
Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the activation of Caspase-3, though the two pathways communicate through the pro-apoptotic Bcl-2 family member Bid before uniting at the shared activation of Caspase-3

external resources
NCBI:1270263
REACTOME:R-HSA-5357769
PUBMED:11048727

genes
FAS , FASLG , CASP3 , CASP8 , CASP9 , CD14 , DAPK1 , DAPK3 , DCC , TLR3 , TLR4 , TRAF2 , TRADD , RIPK1 , TNFSF10 , FADD , TNFRSF10B , TNFRSF10A , CFLAR , MAGED1 , DAPK2 , LY96 , APPL1 , UNC5A , TICAM1 , UNC5B , TICAM2 , MIR637 ,