description
Procaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become accessible for intermolecular processing by the associated procaspase-8 molecule [Keller N et al 2010; Oberst A et al 2010]

external resources
NCBI:1270265
REACTOME:R-HSA-69416
PUBMED:20308068
PUBMED:19851329
PUBMED:12620240

genes
FAS , FASLG , CASP8 , TRAF2 , TRADD , RIPK1 , TNFSF10 , FADD , TNFRSF10B , TNFRSF10A , CFLAR ,