description
CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse

external resources
NCBI:1270310
REACTOME:R-HSA-399956
PUBMED:17607942

genes
CDK5 , CRMP1 , DPYSL2 , DPYSL3 , FES , FYN , GSK3B , PLXNA1 , PLXNA2 , NRP1 , CDK5R1 , SEMA3A , DPYSL4 , PLXNA3 , DPYSL5 , PLXNA4 ,