description
Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion

external resources
NCBI:1270314
REACTOME:R-HSA-373752
PUBMED:18269208
PUBMED:10499167

genes
CDC42 , DCC , DOCK1 , FYN , ABLIM1 , MYO10 , NCK1 , NEO1 , PITPNA , PLCG1 , PRKCQ , PTK2 , PTPN11 , RAC1 , ROBO1 , SIAH1 , SIAH2 , SLIT1 , SLIT3 , SRC , TRIO , TRPC1 , TRPC3 , TRPC4 , TRPC5 , TRPC6 , EZR , UNC5C , WASL , SLIT2 , NTN1 , ABLIM3 , RGMA , TRPC7 , NTN4 , ABLIM2 , UNC5A , AGAP2 , UNC5D , HJV , UNC5B , RGMB ,