description
Depurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Slupphaug et al. 1996, Parikh et al. 1998)

external resources
NCBI:1270353
REACTOME:R-HSA-73927
PUBMED:8900285
PUBMED:9724657

genes
MPG , MUTYH , OGG1 ,