description
Depyrimidination of a damaged nucleotide in DNA is mediated by a pyrimidine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Lindahl and Wood 1999)

external resources
NCBI:1270356
REACTOME:R-HSA-73928
PUBMED:10583946

genes
NTHL1 , OGG1 , TDG , UNG , MBD4 , SMUG1 , NEIL1 , NEIL2 ,