description
DNA polymerase kappa (POLK) is a Y family DNA polymerase that is most efficient in translesion DNA synthesis (TLS) across oxidation derivatives of DNA bases, such as thymine glycol (Tg) and 8-oxoguanine (OGUA), as well as bulky DNA adducts, such as benzo(a)pyrene diol epoxide guanine adduct (BPDE-G) (Zhang et al. 2000, Fischhaber et al.2002, Avkin et al. 2004, Vasquez-Del Carpio et al. 2009, Yoon et al. 2010, Lior-Hoffmann et al. 2012, Christov et al. 2012, Yoon et al. 2014). POLK carries out TLS by forming a quaternary complex with REV1 and POLZ (REV3L:MAD2L2) at DNA damage sites, where POLK simultaneously binds REV1 and monoubiquitinated PCNA (Ohashi et al. 2009, Haracska, Unk et al. 2002, Bi et al. 2006). POLK and POLZ cooperate in the elongation of nucleotides inserted opposite to lesioned bases by POLK. Similarly to POLZ, POLK has low processivity and is error-prone (Ohashi et al. 2000, Haracska, Prakash et al. 2002, Yoon et al. 2010)

external resources
NCBI:1270372
REACTOME:R-HSA-5655862
PUBMED:12444249
PUBMED:11006276
PUBMED:12145297
PUBMED:15475561
PUBMED:11058110
PUBMED:22772988
PUBMED:22721435
PUBMED:11784855
PUBMED:24648516
PUBMED:20660785
PUBMED:19492058
PUBMED:19170759

genes
PCNA , REV3L , RFC1 , RFC2 , RFC3 , RFC4 , RFC5 , RPA1 , RPA2 , RPA3 , RPS27A , UBA52 , UBB , UBC , MAD2L2 , POLK , REV1 ,