description
The initiation and extent of translesion DNA synthesis (TLS) has to be tightly controlled in order to limit TLS-induced mutagenesis, caused by the low fidelity of TLS-participating DNA polymerases. Since monoubiquitination of PCNA at lysine residue K164 is a prerequisite for the assembly of TLS complexes on damaged DNA templates, PCNA deubiquitination is a key step in TLS termination that allows DNA polymerase switching from Y family DNA polymerases involved in TLS to replicative DNA polymerases delta and epsilon (Povlsen et al. 2012, Park et al. 2014)

external resources
NCBI:1270374
REACTOME:R-HSA-5656169
PUBMED:24768535
PUBMED:23000965

genes
PCNA , POLD1 , POLD2 , POLE , POLE2 , POLH , RFC1 , RFC2 , RFC3 , RFC4 , RFC5 , RPA1 , RPA2 , RPA3 , RPS27A , UBA52 , UBB , UBC , UBA7 , TRIM25 , USP10 , UBE2L6 , ISG15 , PCLAF , POLD3 , POLI , POLK , REV1 , POLE3 , POLE4 , POLD4 , USP43 , MIR3614 , MIR5193 ,