description
Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissues to modulate molecular processes in response to such external stresses is essential to the maintenance of tissue homeostasis (Kultz 2005)
external resources
NCBI:1270414
REACTOME:R-HSA-2262752
PUBMED:15709958
genes
NUDT2
,
AQP8
,
ARNT
,
ATM
,
ATOX1
,
ATP7A
,
ATR
,
BAG1
,
BMI1
,
CA9
,
CAMK2A
,
CAMK2B
,
CAMK2D
,
CAMK2G
,
CAT
,
CCNA2
,
CCNE1
,
CDC27
,
CDK2
,
CDK4
,
CDK6
,
CDKN1A
,
CDKN1B
,
CDKN2A
,
CDKN2B
,
CDKN2C
,
CDKN2D
,
CEBPB
,
CREBBP
,
MAPK14
,
CYBA
,
CYBB
,
E2F1
,
E2F2
,
E2F3
,
PHC1
,
PHC2
,
EEF1A1
,
EP300
,
EPAS1
,
EPO
,
ERF
,
ETS1
,
ETS2
,
EZH2
,
FKBP4
,
FOS
,
MTOR
,
GPX1
,
GPX2
,
GPX3
,
GPX5
,
GPX7
,
GSK3B
,
GSR
,
GSTP1
,
H1F0
,
HIST1H1C
,
HIST1H1D
,
HIST1H1E
,
HIST1H1B
,
HIST1H2AE
,
HIST1H2AD
,
H2AFX
,
H2AFZ
,
HIST1H2BD
,
HIST1H2BB
,
H3F3A
,
H3F3B
,
HIST1H1A
,
HIF1A
,
HMGA1
,
HSBP1
,
HSF1
,
HSPA1A
,
HSPA1B
,
HSPA1L
,
HSPA2
,
HSPA4
,
HSPA5
,
HSPA6
,
HSPA7
,
HSPA8
,
HSPA9
,
HSP90AA1
,
HSP90AB1
,
DNAJB1
,
ID1
,
IFNB1
,
IGFBP7
,
IL1A
,
IL6
,
CXCL8
,
JUN
,
LMNB1
,
MDM2
,
MDM4
,
MAP3K5
,
MOV10
,
MRE11
,
NBN
,
NCF2
,
NCF4
,
NFKB1
,
NUP88
,
NUP98
,
P4HB
,
PRDX1
,
PIK3C3
,
PRKAA1
,
PRKAA2
,
PRKAB1
,
PRKAB2
,
PRKAG1
,
MAPK1
,
MAPK3
,
MAPK7
,
MAPK8
,
MAPK11
,
MAPK9
,
MAPK10
,
MAP2K3
,
MAP2K6
,
MAP2K7
,
PSMA1
,
PSMA2
,
PSMA3
,
PSMA4
,
PSMA5
,
PSMA6
,
PSMA7
,
PSMB1
,
PSMB2
,
PSMB3
,
PSMB4
,
PSMB5
,
PSMB6
,
PSMB7
,
PSMB8
,
PSMB9
,
PSMB10
,
PSMC1
,
PSMC2
,
PSMC3
,
PSMC4
,
PSMC5
,
PSMC6
,
PSMD1
,
PSMD2
,
PSMD3
,
PSMD4
,
PSMD5
,
PSMD7
,
PSMD8
,
PSMD9
,
PSMD10
,
PSMD11
,
PSMD12
,
PSMD13
,
PSME1
,
PSME2
,
RANBP2
,
RB1
,
RBBP4
,
RBBP7
,
RELA
,
RHEB
,
RING1
,
RNF2
,
RPA1
,
RPA2
,
RPA3
,
RPS6KA1
,
RPS6KA2
,
RPS6KA3
,
RPS27A
,
MAP2K4
,
SOD1
,
SOD2
,
SOD3
,
SP1
,
ST13
,
STAT3
,
HSPA13
,
ELOC
,
ELOB
,
PRDX2
,
TERF1
,
TERF2
,
TFDP1
,
TFDP2
,
TP53
,
TPR
,
TSC1
,
TSC2
,
DNAJC7
,
HIRA
,
TXN
,
TXNRD1
,
UBA52
,
UBB
,
UBC
,
UBE2D1
,
UBE2D2
,
UBE2D3
,
UBE2E1
,
UVRAG
,
VCP
,
VEGFA
,
VHL
,
YWHAE
,
MAPKAPK3
,
SEM1
,
NUP214
,
AAAS
,
HMGA2
,
HIST3H3
,
HIST1H4I
,
HIST1H2AJ
,
HIST1H2AC
,
HIST1H2AB
,
HIST2H2AA3
,
HIST2H2AC
,
HIST1H2BG
,
HIST1H2BL
,
HIST1H2BN
,
HIST1H2BM
,
HIST1H2BF
,
HIST1H2BE
,
HIST1H2BH
,
HIST1H2BI
,
HIST1H2BC
,
HIST1H2BO
,
HIST2H2BE
,
HIST1H3A
,
HIST1H3D
,
HIST1H3C
,
HIST1H3E
,
HIST1H3I
,
HIST1H3G
,
HIST1H3J
,
HIST1H3H
,
HIST1H3B
,
HIST1H4A
,
HIST1H4D
,
HIST1H4F
,
HIST1H4K
,
HIST1H4J
,
HIST1H4C
,
HIST1H4H
,
HIST1H4B
,
HIST1H4E
,
HIST1H4L
,
HIST2H4A
,
ULK1
,
CUL2
,
RAE1
,
CBX4
,
MAPKAPK5
,
LAMTOR3
,
DYNLL1
,
BECN1
,
CDC23
,
EED
,
CDC16
,
MTMR3
,
CCNA1
,
HIST1H3F
,
HIST1H2BJ
,
LIMD1
,
CCNE2
,
ATG12
,
MAPKAPK2
,
MAP4K4
,
ATG5
,
PSMF1
,
BAG5
,
BAG4
,
BAG3
,
BAG2
,
PRDX6
,
NUP155
,
NUP93
,
ATG13
,
NUP58
,
RB1CC1
,
PSMD6
,
POM121
,
NUP153
,
CCS
,
RBX1
,
HDAC6
,
DNAJB6
,
RAD50
,
PSME3
,
PSMD14
,
RRAGB
,
CITED2
,
ANAPC10
,
KAT5
,
ATG7
,
LAMTOR5
,
TXNRD2
,
RRAGA
,
PTGES3
,
NUP50
,
HSPH1
,
EHMT2
,
PRDX3
,
UBE2C
,
NUPL2
,
WDR45
,
GABARAP
,
GABARAPL2
,
HSPA4L
,
ATG14
,
SCMH1
,
TNIK
,
TNRC6B
,
KDM6B
,
NUP205
,
ATG4B
,
PSME4
,
NUP210
,
NUP160
,
SIRT1
,
CBX6
,
NUP188
,
SUZ12
,
CABIN1
,
NUP62
,
GABARAPL1
,
GABARAPL3
,
PRDX5
,
TXN2
,
ASF1A
,
ANAPC15
,
POT1
,
CHMP2B
,
HIGD1A
,
WIPI2
,
TINF2
,
AGO1
,
DNAJC2
,
CHMP2A
,
TNRC6A
,
LAMTOR2
,
CHMP4A
,
UBN1
,
ANAPC2
,
ANAPC4
,
ERO1A
,
PIK3R4
,
MINK1
,
NOX4
,
HSPA14
,
FZR1
,
PRKAG2
,
ANAPC5
,
ANAPC7
,
HIKESHI
,
ANAPC11
,
CHMP3
,
NUP54
,
PRKAG3
,
CYCS
,
TERF2IP
,
EGLN1
,
LAMTOR1
,
ATG16L1
,
WIPI1
,
AMBRA1
,
HIF1AN
,
NDC1
,
NUP133
,
H2AFJ
,
WDR45B
,
NUP107
,
CBX8
,
RPTOR
,
EP400
,
TNRC6C
,
CCAR2
,
RRAGD
,
ATG101
,
RRAGC
,
MLST8
,
HIF3A
,
MTMR14
,
ATG3
,
ANAPC1
,
ACD
,
NUP37
,
ATG9A
,
NOX5
,
CHMP6
,
EHMT1
,
NUP85
,
PHC3
,
MAP1LC3B
,
SEH1L
,
ATG10
,
AKT1S1
,
MAP1LC3A
,
CBX2
,
ATG4C
,
AJUBA
,
ATG4D
,
HIST1H2BK
,
RPS19BP1
,
CHMP7
,
CHMP4C
,
H2AFV
,
EGLN2
,
EGLN3
,
ATG4A
,
HSPA12B
,
ANAPC16
,
HIST4H4
,
PSMB11
,
WTIP
,
HIST2H3C
,
HIST3H2BB
,
CHMP4B
,
NUP35
,
DYNLL2
,
PSMA8
,
AGO3
,
AGO4
,
CDC26
,
HIST1H2BA
,
GPX6
,
HSPA12A
,
ATG9B
,
HIST2H3A
,
NUP43
,
LAMTOR4
,
C7orf76
,
MAP1LC3C
,
H2AFB1
,
GPX8
,
HIST2H4B
,
NCF1
,
HIST2H3D
,
HIST2H2AA4
,
POM121C
,
SOD2-OT1
,
MIR1281
,
MIR3605
,
LOC100506136
,
MIR4738
,