description
Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissues to modulate molecular processes in response to such external stresses is essential to the maintenance of tissue homeostasis (Kultz 2005)

external resources
NCBI:1270414
REACTOME:R-HSA-2262752
PUBMED:15709958

genes
NUDT2 , AQP8 , ARNT , ATM , ATOX1 , ATP7A , ATR , BAG1 , BMI1 , CA9 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , CAT , CCNA2 , CCNE1 , CDC27 , CDK2 , CDK4 , CDK6 , CDKN1A , CDKN1B , CDKN2A , CDKN2B , CDKN2C , CDKN2D , CEBPB , CREBBP , MAPK14 , CYBA , CYBB , E2F1 , E2F2 , E2F3 , PHC1 , PHC2 , EEF1A1 , EP300 , EPAS1 , EPO , ERF , ETS1 , ETS2 , EZH2 , FKBP4 , FOS , MTOR , GPX1 , GPX2 , GPX3 , GPX5 , GPX7 , GSK3B , GSR , GSTP1 , H1F0 , HIST1H1C , HIST1H1D , HIST1H1E , HIST1H1B , HIST1H2AE , HIST1H2AD , H2AFX , H2AFZ , HIST1H2BD , HIST1H2BB , H3F3A , H3F3B , HIST1H1A , HIF1A , HMGA1 , HSBP1 , HSF1 , HSPA1A , HSPA1B , HSPA1L , HSPA2 , HSPA4 , HSPA5 , HSPA6 , HSPA7 , HSPA8 , HSPA9 , HSP90AA1 , HSP90AB1 , DNAJB1 , ID1 , IFNB1 , IGFBP7 , IL1A , IL6 , CXCL8 , JUN , LMNB1 , MDM2 , MDM4 , MAP3K5 , MOV10 , MRE11 , NBN , NCF2 , NCF4 , NFKB1 , NUP88 , NUP98 , P4HB , PRDX1 , PIK3C3 , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAP2K3 , MAP2K6 , MAP2K7 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RANBP2 , RB1 , RBBP4 , RBBP7 , RELA , RHEB , RING1 , RNF2 , RPA1 , RPA2 , RPA3 , RPS6KA1 , RPS6KA2 , RPS6KA3 , RPS27A , MAP2K4 , SOD1 , SOD2 , SOD3 , SP1 , ST13 , STAT3 , HSPA13 , ELOC , ELOB , PRDX2 , TERF1 , TERF2 , TFDP1 , TFDP2 , TP53 , TPR , TSC1 , TSC2 , DNAJC7 , HIRA , TXN , TXNRD1 , UBA52 , UBB , UBC , UBE2D1 , UBE2D2 , UBE2D3 , UBE2E1 , UVRAG , VCP , VEGFA , VHL , YWHAE , MAPKAPK3 , SEM1 , NUP214 , AAAS , HMGA2 , HIST3H3 , HIST1H4I , HIST1H2AJ , HIST1H2AC , HIST1H2AB , HIST2H2AA3 , HIST2H2AC , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , HIST1H3A , HIST1H3D , HIST1H3C , HIST1H3E , HIST1H3I , HIST1H3G , HIST1H3J , HIST1H3H , HIST1H3B , HIST1H4A , HIST1H4D , HIST1H4F , HIST1H4K , HIST1H4J , HIST1H4C , HIST1H4H , HIST1H4B , HIST1H4E , HIST1H4L , HIST2H4A , ULK1 , CUL2 , RAE1 , CBX4 , MAPKAPK5 , LAMTOR3 , DYNLL1 , BECN1 , CDC23 , EED , CDC16 , MTMR3 , CCNA1 , HIST1H3F , HIST1H2BJ , LIMD1 , CCNE2 , ATG12 , MAPKAPK2 , MAP4K4 , ATG5 , PSMF1 , BAG5 , BAG4 , BAG3 , BAG2 , PRDX6 , NUP155 , NUP93 , ATG13 , NUP58 , RB1CC1 , PSMD6 , POM121 , NUP153 , CCS , RBX1 , HDAC6 , DNAJB6 , RAD50 , PSME3 , PSMD14 , RRAGB , CITED2 , ANAPC10 , KAT5 , ATG7 , LAMTOR5 , TXNRD2 , RRAGA , PTGES3 , NUP50 , HSPH1 , EHMT2 , PRDX3 , UBE2C , NUPL2 , WDR45 , GABARAP , GABARAPL2 , HSPA4L , ATG14 , SCMH1 , TNIK , TNRC6B , KDM6B , NUP205 , ATG4B , PSME4 , NUP210 , NUP160 , SIRT1 , CBX6 , NUP188 , SUZ12 , CABIN1 , NUP62 , GABARAPL1 , GABARAPL3 , PRDX5 , TXN2 , ASF1A , ANAPC15 , POT1 , CHMP2B , HIGD1A , WIPI2 , TINF2 , AGO1 , DNAJC2 , CHMP2A , TNRC6A , LAMTOR2 , CHMP4A , UBN1 , ANAPC2 , ANAPC4 , ERO1A , PIK3R4 , MINK1 , NOX4 , HSPA14 , FZR1 , PRKAG2 , ANAPC5 , ANAPC7 , HIKESHI , ANAPC11 , CHMP3 , NUP54 , PRKAG3 , CYCS , TERF2IP , EGLN1 , LAMTOR1 , ATG16L1 , WIPI1 , AMBRA1 , HIF1AN , NDC1 , NUP133 , H2AFJ , WDR45B , NUP107 , CBX8 , RPTOR , EP400 , TNRC6C , CCAR2 , RRAGD , ATG101 , RRAGC , MLST8 , HIF3A , MTMR14 , ATG3 , ANAPC1 , ACD , NUP37 , ATG9A , NOX5 , CHMP6 , EHMT1 , NUP85 , PHC3 , MAP1LC3B , SEH1L , ATG10 , AKT1S1 , MAP1LC3A , CBX2 , ATG4C , AJUBA , ATG4D , HIST1H2BK , RPS19BP1 , CHMP7 , CHMP4C , H2AFV , EGLN2 , EGLN3 , ATG4A , HSPA12B , ANAPC16 , HIST4H4 , PSMB11 , WTIP , HIST2H3C , HIST3H2BB , CHMP4B , NUP35 , DYNLL2 , PSMA8 , AGO3 , AGO4 , CDC26 , HIST1H2BA , GPX6 , HSPA12A , ATG9B , HIST2H3A , NUP43 , LAMTOR4 , C7orf76 , MAP1LC3C , H2AFB1 , GPX8 , HIST2H4B , NCF1 , HIST2H3D , HIST2H2AA4 , POM121C , SOD2-OT1 , MIR1281 , MIR3605 , LOC100506136 , MIR4738 ,