description
Oxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one aspect of cellular responses to oxygen (Semenza 2004), the role of hypoxia-inducible factor in regulating cellular transcriptional responses to changes in oxygen availability

external resources
NCBI:1270415
REACTOME:R-HSA-2262749
PUBMED:15304631

genes
ARNT , CA9 , CREBBP , EP300 , EPAS1 , EPO , HIF1A , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , ELOC , ELOB , UBA52 , UBB , UBC , UBE2D1 , UBE2D2 , UBE2D3 , VEGFA , VHL , SEM1 , CUL2 , LIMD1 , PSMF1 , PSMD6 , RBX1 , PSME3 , PSMD14 , CITED2 , PSME4 , HIGD1A , EGLN1 , HIF1AN , HIF3A , AJUBA , EGLN2 , EGLN3 , PSMB11 , WTIP , PSMA8 , C7orf76 , MIR1281 , LOC100506136 ,