description
HIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 (Chachami et al. 2009) and importin alpha/beta (Depping et al. 2008). Once in the nucleus HIF-alpha heterodimerizes with HIF-beta (ARNT) (Wang et al. 1995, Jiang et al. 1996, Tian et al. 1997, Gu et al. 1998, Erbel et al. 2003) and recruits CBP and p300 to promoters of target genes (Ebert and Bunn 1998, Kallio et al. 1998, Ema et al. 1999, Gu et al. 2001, Dames et al. 2002, Freedman et al. 2002)

external resources
NCBI:1270419
REACTOME:R-HSA-1234158
PUBMED:9000051
PUBMED:11959990
PUBMED:7539918
PUBMED:18187047
PUBMED:8663540
PUBMED:10202154
PUBMED:14668441
PUBMED:11063749
PUBMED:9840812
PUBMED:11959977
PUBMED:9632793
PUBMED:19788888
PUBMED:9822602

genes
ARNT , CA9 , CREBBP , EP300 , EPAS1 , EPO , HIF1A , VEGFA , CITED2 , HIGD1A , HIF3A , MIR1281 ,