description
Tumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). Stimuli and the cellular context dictate cell fate decisions between survival and death which rely on tightly regulated mechanisms with checkpoints on many levels. TNFR1-mediated NFkappaB activation leads to the pro-survival transcriptional program that is both anti-apoptotic and highly proinflammatory. The constitutive NFkappaB or AP1 activation may lead to excessive inflammation which has been associated with a variety of aggressive tumor types (Jackson-Bernitsas DG et al. 2007; Zhang JY et al. 2007). Thus, the tight regulation of TNFalpha:TNFR1 signaling is required to ensure the appropriate cell response to stimuli

external resources
NCBI:1309094
REACTOME:R-HSA-5357905
PUBMED:22435550
PUBMED:11432772
PUBMED:12724336

genes
BIRC2 , BIRC3 , XIAP , CASP8 , CHUK , CYLD , IKBKB , RPS27A , TNF , TNFAIP3 , TNFRSF1A , TRAF1 , TRAF2 , UBA52 , UBB , UBC , USP4 , IKBKG , MADD , TRADD , RIPK1 , TAX1BP1 , USP2 , RACK1 , RBCK1 , CLIP3 , USP21 , RNF31 , SPPL2B , OTUD7B , SHARPIN , SPPL2A , OTULIN ,