description
DNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010
external resources
NCBI:1309096
REACTOME:R-HSA-5693606
PUBMED:20965415
genes
ABL1
,
APBB1
,
ATM
,
BARD1
,
BRCA1
,
EYA4
,
EYA1
,
EYA2
,
EYA3
,
H2AFX
,
HIST1H2BD
,
HIST1H2BB
,
KPNA2
,
MRE11
,
NBN
,
PPP5C
,
MAPK8
,
RPS27A
,
TP53
,
TP53BP1
,
UBA52
,
UBB
,
UBC
,
UBE2I
,
UBE2N
,
UBE2V2
,
SUMO1
,
NSD2
,
HIST3H3
,
HIST1H4I
,
BAP1
,
HIST1H2BG
,
HIST1H2BL
,
HIST1H2BN
,
HIST1H2BM
,
HIST1H2BF
,
HIST1H2BE
,
HIST1H2BH
,
HIST1H2BI
,
HIST1H2BC
,
HIST1H2BO
,
HIST2H2BE
,
HIST1H4A
,
HIST1H4D
,
HIST1H4F
,
HIST1H4K
,
HIST1H4J
,
HIST1H4C
,
HIST1H4H
,
HIST1H4B
,
HIST1H4E
,
HIST1H4L
,
HIST2H4A
,
SMARCA5
,
HERC2
,
HIST1H2BJ
,
RNF8
,
BAZ1B
,
BABAM2
,
MDC1
,
KDM4A
,
RAD50
,
KAT5
,
CHEK2
,
KDM4B
,
BABAM1
,
PIAS4
,
UIMC1
,
BRCC3
,
ABRAXAS1
,
HIST1H2BK
,
HIST4H4
,
HIST3H2BB
,
RNF168
,
HIST1H2BA
,
HIST2H4B
,
