description
DNA double strand break (DSB) response involves sensing of DNA DSBs by the MRN complex which triggers ATM activation. ATM phosphorylates a number of proteins involved in DNA damage checkpoint signaling, as well as proteins directly involved in the repair of DNA DSBs. For a recent review, please refer to Ciccia and Elledge, 2010

external resources
NCBI:1309096
REACTOME:R-HSA-5693606
PUBMED:20965415

genes
ABL1 , APBB1 , ATM , BARD1 , BRCA1 , EYA4 , EYA1 , EYA2 , EYA3 , H2AFX , HIST1H2BD , HIST1H2BB , KPNA2 , MRE11 , NBN , PPP5C , MAPK8 , RPS27A , TP53 , TP53BP1 , UBA52 , UBB , UBC , UBE2I , UBE2N , UBE2V2 , SUMO1 , NSD2 , HIST3H3 , HIST1H4I , BAP1 , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , HIST1H4A , HIST1H4D , HIST1H4F , HIST1H4K , HIST1H4J , HIST1H4C , HIST1H4H , HIST1H4B , HIST1H4E , HIST1H4L , HIST2H4A , SMARCA5 , HERC2 , HIST1H2BJ , RNF8 , BAZ1B , BABAM2 , MDC1 , KDM4A , RAD50 , KAT5 , CHEK2 , KDM4B , BABAM1 , PIAS4 , UIMC1 , BRCC3 , ABRAXAS1 , HIST1H2BK , HIST4H4 , HIST3H2BB , RNF168 , HIST1H2BA , HIST2H4B ,