description
The nuclear pore complex (NPC) trafficks cargo across the nuclear membrane. Nucleoprotein TRP functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. The complex glucokinase (GCK1) and glucokinase regulatory protein (GKRP) can be translocated to the nucleus via the NPC. Defects in TRP may confer susceptibility towards thyroid papillary carcinona (TPC; MIM:18850), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue (Vriens et al. 2009, Bonora et al. 2010)

external resources
NCBI:1309193
REACTOME:R-HSA-5619107
PUBMED:20001717
PUBMED:20628519

genes
GCK , GCKR ,