description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively

external resources
NCBI:1311074
KEGG:hsa04072
PUBMED:9310372
PUBMED:9119890
PUBMED:15310762
PUBMED:18936782
PUBMED:24990952
PUBMED:14769825
PUBMED:21936578
PUBMED:10666319
PUBMED:17210675
PUBMED:19264150
PUBMED:23076158
PUBMED:17054901
PUBMED:16622417
PUBMED:10807766
PUBMED:12217395
PUBMED:11042115
PUBMED:19815110
PUBMED:24995811
PUBMED:16143829
PUBMED:8135758
PUBMED:11991733
PUBMED:19410013
PUBMED:17245604

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , AGTR1 , AKT1 , AKT2 , ARF1 , ARF6 , RHOA , AVP , AVPR1A , AVPR1B , AVPR2 , DGKA , DGKB , DGKG , DGKQ , DNM1 , DNM2 , LPAR1 , EGF , EGFR , F2R , PTK2B , FCER1A , MS4A2 , FCER1G , MTOR , FYN , GAB1 , GNA12 , GNAS , LPAR4 , GRB2 , GRM1 , GRM2 , GRM3 , GRM4 , GRM5 , GRM6 , GRM7 , GRM8 , HRAS , CXCL8 , CXCR1 , CXCR2 , INS , INSR , KIT , KRAS , KITLG , NRAS , PDGFA , PDGFB , PDGFRA , PDGFRB , PIK3CA , PIK3CB , PIK3CD , PIK3CG , PIK3R1 , PIK3R2 , PLA2G4A , PLCB2 , PLCB3 , PLCB4 , PLCG1 , PLCG2 , PLD1 , PLD2 , PRKCA , MAPK1 , MAPK3 , MAP2K1 , MAP2K2 , PTGFR , PTPN11 , RAF1 , RALA , RALB , RALGDS , RHEB , RRAS , SHC1 , SOS1 , SOS2 , SYK , TSC1 , TSC2 , PIP5K1A , PIP5K1B , PIK3R3 , DGKZ , DGKE , DGKD , PLA2G4C , PLPP1 , PLPP2 , PLPP3 , JMJD7-PLA2G4B , SPHK1 , DGKI , LPAR2 , CYTH3 , CYTH2 , CYTH1 , GAB2 , AKT3 , LPAR6 , RAPGEF3 , AGPAT1 , AGPAT2 , GNA13 , RAPGEF4 , RRAS2 , MRAS , PLCB1 , PIP5K1C , PIK3R5 , LPAR3 , SHC2 , DNM3 , CYTH4 , SHC3 , AGPAT5 , PDGFC , SPHK2 , AGPAT3 , AGPAT4 , LPAR5 , PDGFD , PLA2G4E , DGKK , PIK3R6 , DGKH , ADCY4 , PLA2G4F , PLA2G4D , SHC4 , PLA2G4B ,