description
Fucose-containing glycans play important roles in immunity and signalling. Fucosylated glycans are created by fucosyltransferases, which require the high-energy donor substrate GDP-fucose. Two pathways for the synthesis of GDP-fucose exist in mammalian cells; the GDP-mannose-dependent de novo pathway provides the majority of GDP-fucose whereas a minor contribution comes from the free fucose-dependent salvage pathway (Becker & Lowe 2003)

external resources
NCBI:1339108
REACTOME:R-HSA-6787639
PUBMED:12651883

genes
GMDS , TSTA3 , FPGT , SLC35C1 , FUK , FUOM ,