description
The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013)

external resources
NCBI:1339109
REACTOME:R-HSA-6807878
PUBMED:9323141
PUBMED:15632110
PUBMED:10825291
PUBMED:9288971
PUBMED:23378591
PUBMED:8334707
PUBMED:22013193
PUBMED:23732476

genes
ANK1 , ANK2 , ANK3 , ARCN1 , ARF1 , ARF3 , ARF4 , ARF5 , CD59 , COPA , COPB1 , CD55 , DCTN1 , DYNC1H1 , DYNC1I1 , DYNC1I2 , DYNC1LI2 , FOLR1 , GOLGA2 , GOLGB1 , INS , NSF , RAB1A , SPTA1 , SPTAN1 , SPTB , SPTBN1 , SPTBN2 , STX5 , USO1 , DYNLL1 , GBF1 , NAPG , NAPA , COPB2 , COG1 , GOSR1 , GOSR2 , BET1 , COG5 , DCTN2 , YKT6 , DCTN6 , KDELR1 , TMED2 , TMED10 , KDELR2 , KDELR3 , TMEM115 , DCTN3 , COPE , COG2 , COPZ1 , COPG1 , TMED3 , COG4 , ARFGAP3 , COPG2 , TMED7 , DYNC1LI1 , DCTN4 , COPZ2 , BET1L , SPTBN5 , TMED9 , ARFGAP1 , COG6 , SPTBN4 , NAPB , GORASP1 , RAB1B , COG3 , COG8 , ARFGAP2 , DCTN5 , COG7 , DYNLL2 , MIR3620 ,