description
Proteins classified as transcription factors constitute a disproportionate number of SUMOylation targets. In most cases SUMOylation inhibits transcriptional activation, however in some cases such as TP53 (p53) SUMOylation can enhance activation. Inhibition of transcription by SUMOylation may be due to interference with DNA binding, re-localization to inactive nuclear bodies, or recruitment of repressive cofactors such as histone deacetylases (reviewed in Girdwood et al. 2004, Gill 2005)

external resources
NCBI:1339110
REACTOME:R-HSA-3232118
PUBMED:16095902
PUBMED:21892772
PUBMED:19107415
PUBMED:19616654
PUBMED:15209380
PUBMED:18031228

genes
CDKN2A , MDM2 , MITF , SUMO3 , SUMO2 , SP3 , TFAP2A , TFAP2B , TFAP2C , TP53 , TP53BP1 , UBE2I , SUMO1 , PIAS1 , MTA1 , PIAS3 , PIAS4 ,