description
The sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-strand breaks and inappropriate recombination (reviewed in Watts 2006, Watts 2007, Dieckman et al. 2012, Gazy and Kupiec 2012). SUMOylation of Aurora-A, Aurora-B, and Borealin is necessary for proper chromosome segregation. SUMOylation of topoisomerases is observed in response to damage caused by inhibitors of topoisomerases

external resources
NCBI:1339113
REACTOME:R-HSA-4615885
PUBMED:22812528
PUBMED:17031663
PUBMED:22918591
PUBMED:22732495
PUBMED:16368276

genes
BIRC5 , INCENP , NUP88 , NUP98 , PCNA , RANBP2 , RANGAP1 , SUMO3 , SUMO2 , AURKA , TOP1 , TOP2A , TOP2B , TPR , UBE2I , SUMO1 , NUP214 , AAAS , RAE1 , AURKB , NUP155 , NUP93 , NUP58 , POM121 , NUP153 , PIAS3 , NUP50 , NUPL2 , NUP205 , NUP210 , NUP160 , NUP188 , NUP62 , PIAS4 , NUP54 , CDCA8 , NDC1 , NUP133 , NUP107 , NUP37 , NUP85 , SEH1L , NUP35 , NUP43 , POM121C , MIR4442 ,