description
Phase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. The cell's excitation opens the closed, fast Na+ channel proteins, causing a large influx of Na+ creating a Na+ current (INa+). This causes depolarisation of the cell then voltage-dependent L-type calcium channels (LTCCs) transport Ca2+ into excitable cells. The slope of phase 0 represents the maximum rate of potential change and differs in contractile and pacemaker cells. The potential in this phase changes from around -90mV to around +50mV (Park & Fishman 2011, Grant 2009)

external resources
NCBI:1339117
REACTOME:R-HSA-5576892
PUBMED:21357845
PUBMED:19808464

genes
CACNA1C , CACNA1D , CACNA1F , CACNA1S , CACNA2D1 , CACNB1 , CACNB2 , CACNB3 , CACNB4 , CACNG1 , CALM1 , CALM2 , CALM3 , CAMK2A , CAMK2B , CAMK2D , CAMK2G , FGF11 , FGF12 , FGF13 , FGF14 , SCN1A , SCN1B , SCN2A , SCN2B , SCN3A , SCN4A , SCN4B , SCN5A , SCN7A , SCN8A , SCN9A , SCN10A , CACNA2D2 , CACNG3 , CACNG2 , SCN11A , CACNG5 , CACNG4 , RANGRF , CACNA2D3 , SCN3B , CACNG8 , CACNG7 , CACNG6 , CACNA2D4 , MIR935 ,