description
Phase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. The cell's excitation opens the closed, fast Na+ channel proteins, causing a large influx of Na+ creating a Na+ current (INa+). This causes depolarisation of the cell then voltage-dependent L-type calcium channels (LTCCs) transport Ca2+ into excitable cells. The slope of phase 0 represents the maximum rate of potential change and differs in contractile and pacemaker cells. The potential in this phase changes from around -90mV to around +50mV (Park & Fishman 2011, Grant 2009)
external resources
NCBI:1339117
REACTOME:R-HSA-5576892
PUBMED:21357845
PUBMED:19808464
genes
CACNA1C
,
CACNA1D
,
CACNA1F
,
CACNA1S
,
CACNA2D1
,
CACNB1
,
CACNB2
,
CACNB3
,
CACNB4
,
CACNG1
,
CALM1
,
CALM2
,
CALM3
,
CAMK2A
,
CAMK2B
,
CAMK2D
,
CAMK2G
,
FGF11
,
FGF12
,
FGF13
,
FGF14
,
SCN1A
,
SCN1B
,
SCN2A
,
SCN2B
,
SCN3A
,
SCN4A
,
SCN4B
,
SCN5A
,
SCN7A
,
SCN8A
,
SCN9A
,
SCN10A
,
CACNA2D2
,
CACNG3
,
CACNG2
,
SCN11A
,
CACNG5
,
CACNG4
,
RANGRF
,
CACNA2D3
,
SCN3B
,
CACNG8
,
CACNG7
,
CACNG6
,
CACNA2D4
,
MIR935
,
