description
Transcription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). Depending on the growth state of the cell, about half of the approximately 400 rRNA genes are expressed and these have the modifications characteristic of active chromatin: unmethylated DNA and acetylated histones. Repressed genes generally have methylated DNA and histone H3 methylated at lysine-9. Regulators of activation include ERCC6 (CSB), histone acetylases such as KAT2B (PCAF), and the B-WICH complex. Dysregulation of RNA polymerase I transcription plays a role in disease (reviewed in Hannan et al. 2013)

external resources
NCBI:1339125
REACTOME:R-HSA-5250913
PUBMED:23153826
PUBMED:16574391
PUBMED:23063748
PUBMED:23150253
PUBMED:18616426

genes
ACTB , CHD3 , CHD4 , EP300 , ERCC6 , KAT2A , GSK3B , HIST1H2AE , HIST1H2AD , H2AFX , H2AFZ , HIST1H2BD , HIST1H2BB , H3F3A , H3F3B , HDAC1 , HDAC2 , MYO1C , POLR2E , POLR2F , POLR2H , POLR2K , POLR2L , RBBP4 , RBBP7 , TBP , TTF1 , DEK , HIST1H4I , HIST1H2AJ , HIST1H2AC , HIST1H2AB , HIST2H2AA3 , HIST2H2AC , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , HIST1H3A , HIST1H3D , HIST1H3C , HIST1H3E , HIST1H3I , HIST1H3G , HIST1H3J , HIST1H3H , HIST1H3B , HIST1H4A , HIST1H4D , HIST1H4F , HIST1H4K , HIST1H4J , HIST1H4C , HIST1H4H , HIST1H4B , HIST1H4E , HIST1H4L , HIST2H4A , SMARCA5 , KAT2B , HIST1H3F , HIST1H2BJ , TAF1C , TAF1B , TAF1A , BAZ1B , MTA1 , DDX21 , MTA2 , POLR1C , MYBBP1A , CD3EAP , EHMT2 , CBX3 , SF3B1 , POLR1A , ZNRD1 , POLR1D , MBD3 , GATAD2A , H2AFJ , GATAD2B , MTA3 , POLR1E , TAF1D , POLR1B , HIST1H2BK , H2AFV , HIST4H4 , HIST2H3C , HIST3H2BB , TWISTNB , HIST1H2BA , HIST2H3A , H2AFB1 , HIST2H4B , HIST2H3D , HIST2H2AA4 , MIR1281 , MIR1304 , MIR4738 ,