description
TPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. 2003, Xu et al. 2011, Giubettini et al. 2011, Dodson and Bayliss 2012)

external resources
NCBI:1383018
REACTOME:R-HSA-8854518
PUBMED:14580337
PUBMED:21147853
PUBMED:22094468
PUBMED:21347367

genes
CDK1 , CETN2 , CSNK1D , CSNK1E , DCTN1 , DYNC1H1 , DYNC1I2 , HMMR , HSP90AA1 , NEK2 , ODF2 , PAFAH1B1 , PCM1 , PCNT , PLK1 , PPP2R1A , PRKACA , PRKAR2B , AURKA , TUBA4A , TUBG1 , YWHAE , YWHAG , ALMS1 , TUBA1A , OFD1 , SSNA1 , DYNLL1 , CEP135 , CEP57 , CCP110 , CKAP5 , SFI1 , ACTR1A , AKAP9 , TUBB4A , TUBB4B , DCTN2 , PLK4 , SDCCAG8 , CNTRL , FGFR1OP , CEP250 , DCTN3 , CEP164 , MAPRE1 , TPX2 , NINL , CEP131 , CEP152 , CLASP1 , HAUS5 , HAUS6 , NDE1 , HAUS4 , CEP192 , HAUS2 , HAUS7 , CEP72 , CDK5RAP2 , CENPJ , HAUS3 , CEP76 , CEP290 , CEP63 , CEP70 , CEP78 , HAUS8 , CEP41 , HAUS1 , NEDD1 , TUBB , MIR484 , MIR4707 ,