description
PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011)

external resources
NCBI:1383024
REACTOME:R-HSA-8847993
PUBMED:20687930
PUBMED:1349015
PUBMED:26247733
PUBMED:18719096
PUBMED:8940083
PUBMED:21847121

genes
BTC , HBEGF , EGF , EGFR , ERBB2 , ERBB3 , ERBB4 , EREG , NRG1 , PTK6 , NRG2 , NRG3 , NRG4 ,