description
PTK6 enhances EGFR signaling by inhibiting EGFR down-regulation (Kang et al. 2010, Li et al. 2012, Kang and Lee 2013). PTK6 may also enhance signaling by other receptor tyrosine kinases (RTKs), such as IGF1R (Fan et al. 2013) and ERBB3 (Kamalati et al. 2000).PTK6 affects AKT1 activation (Zhang et al. 2005, Zheng et al. 2010) and targets negative regulator of RTKs, DOK1, for degradation (Miah et al. 2014)

external resources
NCBI:1383031
REACTOME:R-HSA-8849469
PUBMED:20606012
PUBMED:22231447
PUBMED:11114724
PUBMED:15539407
PUBMED:24523872
PUBMED:20554524
PUBMED:23814047
PUBMED:23352614

genes
AKT1 , CBL , DOK1 , PTK6 , RPS27A , UBA52 , UBB , UBC , ARAP1 ,