description
In addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo such as glycosylation enzymes and Shiga and Shiga-like toxin through tubular carriers rather than vesicles (White et al, 1999; Girod et al, 1999; reviewed in Heffernan and Simpson, 2014). In the absence of a COPI coat, the membrane curvature necessary to initiate tubulation may be provided through the action of phospholipase A, which hydrolyzes phospholipids at the sn2 position to yield lysophospholipids. This activity is countered by lysophospholipid acyltransferases, and the balance of these may influence whether transport tubules or transport vesicles form (de Figuiredo et al, 1998; reviewed in Bechler et al, 2012). RAB6-dependent tubules also depend on the dynein-dynactin motor complex and the hoomodimeric Bicaudal proteins (Matanis et al, 2002; Yamada et al, 2013; reviewed in Heffernan and Simpson, 2014)

external resources
NCBI:1383043
REACTOME:R-HSA-6811436
PUBMED:23783758
PUBMED:9671731
PUBMED:25233431
PUBMED:22130221
PUBMED:10559986
PUBMED:12447383
PUBMED:10562278

genes
BICD1 , DCTN1 , DYNC1H1 , DYNC1I1 , DYNC1I2 , DYNC1LI2 , GALNT1 , GALNT2 , PAFAH1B1 , PAFAH1B2 , PAFAH1B3 , PLA2G4A , RAB6A , PLA2G6 , DYNLL1 , DCTN2 , DCTN6 , DCTN3 , RAB3GAP1 , RAB18 , BICD2 , RAB3GAP2 , DYNC1LI1 , DCTN4 , RAB6B , AGPAT3 , DCTN5 , DYNLL2 ,