description
Human beta-1,3-glucosyltransferase like protein (B3GALTL, HGNC Approved Gene Symbol: B3GLCT; MIM:610308; CAZy family GT31), localised on the ER membrane, glucosylates O-fucosylated proteins. The resultant glc-beta-1,3-fuc disaccharide modification on thrombospondin type 1 repeat (TSR1) domain-containing proteins is thought to assist in the secretion of many of these proteins from the ER lumen, and mediate an ER quality-control mechanism of folded TSRs (Vasudevan et al. 2015). Defects in B3GALTL can cause Peters plus syndrome (PpS; MIM:261540), an autosomal recessive disorder characterised by anterior eye chamber defects, short stature, delay in growth and mental developmental and cleft lip and/or palate (Heinonen & Maki 2009)

external resources
NCBI:1383054
REACTOME:R-HSA-5083635
PUBMED:25544610
PUBMED:18720094

genes
CFP , THBS1 , THBS2 , SEMA5A , ADAMTS4 , ADAMTS3 , ADAMTS2 , ADAMTS1 , ADAMTSL2 , SPON2 , SPON1 , ADAMTS13 , ADAMTS8 , ADAMTS5 , ADAMTS7 , ADAMTS6 , SSPO , SEMA5B , ADAMTSL4 , THSD1 , ADAMTS9 , ADAMTSL3 , THSD4 , ADAMTS20 , THSD7B , ADAMTS12 , ADAMTS10 , ADAMTSL1 , ADAMTS14 , SBSPON , ADAMTS15 , ADAMTS16 , ADAMTS17 , ADAMTS18 , ADAMTS19 , THSD7A , ADAMTSL5 ,