description
Pro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010)

external resources
NCBI:1383067
REACTOME:R-HSA-6803211
PUBMED:15289308
PUBMED:19615968
PUBMED:7566179
PUBMED:9326928
PUBMED:23365256
PUBMED:10777207
PUBMED:14623878
PUBMED:20353938
PUBMED:16230375
PUBMED:11382926

genes
FAS , IGFBP3 , TP53 , TP53BP2 , TP73 , TP63 , TNFRSF10D , TNFRSF10C , TNFRSF10B , TNFRSF10A , PPP1R13B , TMEM219 ,