description
Apoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and probably BNIP3L, AIFM2, STEAP3, TRIAP1 and TP53AIP1 (Miyashita and Reed 1995, Oda et al. 2000, Samuels-Lev et al. 2001, Nakano and Vousden 2001, Sax et al. 2002, Passer et al. 2003, Bergamaschi et al. 2004, Li et al. 2004, Fei et al. 2004, Wu et al. 2004, Park and Nakamura 2005, Patel et al. 2008, Wang et al. 2012, Wilson et al. 2013), thus promoting the activation of the apoptotic pathway.Transcriptional activation of TP53AIP1 requires phosphorylation of TP53 at serine residue S46 (Oda et al. 2000, Taira et al. 2007). Phosphorylation of TP53 at S46 is regulated by another TP53 pro-apoptotic target, TP53INP1 (Okamura et al. 2001, Tomasini et al. 2003)

external resources
NCBI:1383068
REACTOME:R-HSA-6803204
PUBMED:12606722
PUBMED:18676979
PUBMED:11511362
PUBMED:11463392
PUBMED:10807576
PUBMED:12851404
PUBMED:12402042
PUBMED:15273740
PUBMED:14729977
PUBMED:15735003
PUBMED:15126337
PUBMED:23365256
PUBMED:22766503
PUBMED:11684014
PUBMED:15607964
PUBMED:7834749

genes
ATM , BAX , BID , BNIP3L , CREBBP , PMAIP1 , TP53 , TP53BP2 , TP73 , TP63 , PRELID3A , PPP1R13B , BBC3 , PRELID1 , TRIAP1 , STEAP3 , TP53AIP1 , AIFM2 , TP53INP1 , ZNF420 , MIR3191 ,