description
TP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are involved either in the intrinsic apoptosis pathway or in the extrinsic apoptosis pathway triggerred by death receptors or the inflammation-related cell death pyroptosis (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007)

external resources
NCBI:1383069
REACTOME:R-HSA-6803207
PUBMED:15580302
PUBMED:14688482
PUBMED:10973264
PUBMED:11278253
PUBMED:12089322
PUBMED:11559530
PUBMED:17284521

genes
APAF1 , ATM , CASP1 , CASP2 , CASP6 , CASP10 , TP53 , TP73 , TP63 , CRADD , PIDD1 , NLRC4 ,