description
Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The major players are caspases, caspase inhibitors, members of the Bcl-2 family of pro- and anti-apoptotic proteins and adaptors of the Ced-4/APAF-1 type. Mammals, by comparison with Caenorhabditis and Drosophila, exhibit highly complex extrinsic and intrinsic pathways for apoptosis induction. However, recent analyses of whole genome sequences from cnidarians (e.g. Hydra) suggest that the caspase and Bcl-2 families were already highly complex in cnidarians and that Caenorhabditis and Drosophila lost many of the genes involved in apoptosis

external resources
NCBI:1384747
KEGG:hsa04215
PUBMED:23457257
PUBMED:11858838
PUBMED:15963254
PUBMED:20041301
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PUBMED:20479784
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PUBMED:25862972
PUBMED:20028968
PUBMED:25991373

genes
APAF1 , BIRC2 , BIRC3 , XIAP , BIRC5 , BAK1 , BAX , BCL2 , BCL2L1 , BID , BOK , CASP3 , CASP7 , CASP8 , CASP9 , NGFR , PMAIP1 , SEPT4 , MAPK8 , MAPK9 , MAPK10 , TNFRSF1A , BECN1 , FADD , BCL2L11 , BBC3 , HTRA2 , CYCS , DIABLO , BIRC6 , BIRC7 , BIRC8 , BECN2 ,