description
TFAP2A and TFAP2C directly stimulate transcription of the estrogen receptor ESR1 gene (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer, and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998). TFAP2A, TFAP2C, as well as TFAP2B can directly stimulate the expression of ERBB2, another important breast cancer gene (Bosher et al. 1996). Association of TFAP2A with the YY1 transcription factor significantly increases the ERBB2 transcription rate (Begon et al. 2005). In addition to ERBB2, the expression of another receptor tyrosine kinase, KIT, is also stimulated by TFAP2A and TFAP2B (Huang et al. 1998), while the expression of the VEGF receptor tyrosine kinase ligand VEGFA is repressed by TFAP2A (Ruiz et al. 2004, Li et al. 2012). TFAP2A stimulates transcription of the transforming growth factor alpha (TGFA) gene (Wang et al. 1997). TFAP2C regulates EGFR expression in luminal breast cancer (De Andrade et al. 2016). In placenta, TFAP2A and TFAP2C directly stimulate transcription of both subunits of the human chorionic gonadotropin, CGA and CGB (Johnson et al. 1997, LiCalsi et al. 2000)

external resources
NCBI:1427841
REACTOME:R-HSA-8866910
PUBMED:14744778
PUBMED:9162057
PUBMED:22735262
PUBMED:26832794
PUBMED:10648798
PUBMED:10497269
PUBMED:9850080
PUBMED:9687504
PUBMED:7891714
PUBMED:15870067
PUBMED:9182571
PUBMED:8895516

genes
CGA , CGB3 , EGFR , ERBB2 , ESR1 , KIT , TFAP2A , TFAP2B , TFAP2C , TGFA , VEGFA , YY1 , ATAD2 , CGB5 , CGB8 ,