description
DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997)

external resources
NCBI:1427861
REACTOME:R-HSA-5689603
PUBMED:16325574
PUBMED:19243136

genes
ACTB , ACTL6A , BARD1 , HIST1H2AE , HIST1H2AD , HCFC1 , FOXK2 , SMAD7 , NEDD8 , NFRKB , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , RPS27A , TGFB1 , TGFBR1 , TGFBR2 , UBA52 , UBB , UBC , UCHL1 , UCHL3 , YY1 , SEM1 , BAP1 , HIST1H2AI , HIST1H2AK , HIST1H2AJ , HIST1H2AL , HIST1H2AC , HIST1H2AB , HIST1H2AM , HIST2H2AA3 , HIST2H2AC , OGT , RUVBL1 , HIST1H2AG , PSMF1 , PSMD6 , USP15 , PSME3 , PSMD14 , MCRS1 , ADRM1 , PSME4 , TFPT , UCHL5 , INO80 , INO80D , ASXL2 , MBD5 , ACTR5 , INO80B , HIST1H2AH , HIST3H2A , ACTR8 , MBD6 , PSMB11 , SENP8 , INO80C , PSMA8 , ASXL1 , HIST1H2AA , KDM1B , FOXK1 , INO80E , HIST2H2AB , C7orf76 , HIST2H2AA4 , LOC100506136 ,